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Quantitative Amino Acid Analysis of Extracted Soyabean Meal Hydrolysates by Ion Exchange Chromatography Siwela, Andrew H. , 1985 Although there are tables of amino acids In foods and feeding stuffs written by authorities in the field, it is felt that there is a need for such tables appertaining to Zimbabwean conditions. As a first step to this objective a survey was undert[more...]
The effect of schistosomiasis on the activation of aflatoxin B1 Hasler, Julia A. ; Siwela, Andrew H. ; Nyathi, C.B. ; Chetsanga, C.J. , 1986-03 This study examined activation of aflatoxin Bl (AFB1) in livers of Schistosomamansoni-infected and noninfected mice by measuring covalent binding of ('H]AFBl to cellular macromolecules in vivo and in vitro. During a one week time period after AFB1 tr[more...]
Aflatoxin Contamination of Stored Groundnuts in Zimbabwe. Siwela, Andrew H. ; Caley, A.D. , 1989 Aflatoxins were analyzed in groundnuts stored for either local or export sales in the period 1982/83 to 1986/87. Four hundred and forty-one samples of seven groundnut varieties were collected for analysis. Sixty-eight percent of the samples had tot[more...]
The Effect Of Three Species Of Schistosomes On Hepatic Drug Metabolism In Male BALB/ Mice Naik, Yogeshkumar S. ; Basopo, N. , 1990 Schistosomiasis is a parasitic disease that affects over 200 million people in the world. S.mansoni and S.haematobium are of medical importance while S.mattheei is primarily of veterinary concern. It is important to know the effect that the disease h[more...]
The effect of schistosomiasis on the covalent binding of 2-acetylaminofluorene to mouse liver macromolecules in vivo and in vitro Siwela, Andrew H. ; Nyathi, C.B. ; Chetsanga, C.J. ; Hasler, Julia A. , 1990-07-15 The covalent binding of [14C]acetylaminofluorene (AAF) to macromolecules in vivo and in vitro was measured in Schistosoma mansoni-infected and in non-infected mice. Liver microsomes from infected mice demonstrated a 42% decreased capacity to mediate [more...]
Effects of phenobarbital and 3-methylcholanthrene pretreatment on the pharmacokinetics of praziquantel in rats. Masimirembwa, Collen M. ; Naik, Yogeshkumar S. ; Hasler, Julia A. , 1992-06-25 The effects of phenobarbital (PB) and 3-methylcholanthrene (MC) pretreatment on the phannac~kinetics of praziquantel (PZQ), a schistosomicide were studied in Spnrgue-Dawley rats. Blood samples at different time intervals were obtained by severing th[more...]
Fault-plane solutions of the Deka Fault zone and mid-zambezi Valley Hlatywayo, Dumisani J. , 1993-07-08 An analysis of twenty-one fault-plane solutions from the Deka Fault zone and the mid-Zambezi Valley shows normal (dip-slip) faulting with a strike-slip component. The fault planes strike in a south-westerly direction in conformity with the north-e[more...]
Xenobiotic metabolizing enzymes of the freshwater snails.Planorbella and lymnaea (RADIX)Natalensis. Naik, Yogeshkumar S. ; Magwere, Tapiwanashe ; Matiyenga, M. ; Hasler, Julia A. , 1994 Very little is known about the ability of snails to metabolise and remove xenobiotics such as molluscicides. The present study was conducted to determine whether the freshwater snails Planorbella duryi and Lymnaea (Radix) nntaIensis possess two of t[more...]
Hepatic Cytosolic Glutathione S-Transferases Of Ostrich (Struthio Camelus): Partial Characterization And Interaction With Xenobiotics Naik, Yogeshkumar S. ; Kanyepi, R. ; Ndiweni, N. ; Nasler, J.A. , 1994 The glutathione S-transferases (GSTs) in affinity purified pools of male and female ostrich liver were studied. The GSTs were purified from crude liver cytosols by S-hexylglutathione sepharose affinity chromatography with yields comparable to thos[more...]
A Comparison Of Organochlorine Pesticide Residues In Upper Ncema And Lower Umguza Dams, Zimbabwe. Siwela, Andrew H. ; Marufu, G. ; Mhlanga, A.T. , 1996 This study examined the levels of chlorinated hydrocarbons (organochloride pesticides) in the ecosystem of Ncema and Umguza dams. Samples of water, water weeds, mud and fish were collected from each dam. The fish species collected from the two dam[more...]
Combined use of phenyl-bonded phase clean-up and HPLC for the determination of aflatoxins Siwela, Andrew H. , 1996 Phenyl·bonded phase clean-up and HPLC were used to measure aflatoxins in groundnuts, peanut butter, beans, cowpeas and maize meant for human consumption. Of 277 samples, 84% were al or bleow the 20 pp.b. limil. Of 100 animal feed samples, 28% were[more...]
Effects of chloroquine treatment on antioxidant enzymes in rat liver and kidney. Magwere, Tapiwanashe ; Naik, Yogeshkumar S. ; Hasler, Julia A. , 1996-05-09 The effect of chloroquine (CHQ) administration on antioxidant enzymes in rat liver and kidney was studied. Male Sprague-Dawley rats were administered 20 mglkg CHQ once a week for 4 weeks (chronic treatment) or a single dose at 10 or 20 mglkg (acute[more...]
Alteration of paracetamol pharmacokinetics in BALB/C mice infected with Schistosoma mansoni Mukanganyama, Stanley ; Naik, Yogeshkumar S. ; Hasler, Julia A. , 1997 Objective: To determine whether the BALBIC mouse is a suitable model for the study of drug pharmacokinetics in S.rnansoni infection. Design: Male and female BALBIC mice were exposed to cercariae of Smansoni. At the acute (eight weeks post infectio[more...]
POM: a highly visual production and operations Onwubolu, Godfrey C. ; Mhlanga, Samson , 1997 [more...]
Phenotyping of the glutathione S-transferase M1 polymorphism in Zimbabweans and the effects of chloroquine on blood glutathione S-transferases M1-A Mukanganyama, Stanley ; Masimirembwa, Collen M. ; Naik, Yogeshkumar S. ; Hasler, Julia A. , 1997-05-31 The frequency of the null allele phenotype of glutathione S-transferase (GST) M1 was investigated in 114 Zimbabweans and results for a subset of 63 subjects were compared with genotyping by PCR. In addition, the effect of the antimalarial chloroquin[more...]
The Effect of Schistosoma Mansoni Infection on the Hepatic Drug Metabolizing Enzymes of Mice and Hamsters Naik, Yogeshkumar S. ; Hasler, Julia A. , 1998 Discusses the effect of schistosome infection on hepatic drug metabolizing enzymes. Examples of drug metabolizing enzymes; Effect of liver disease of drug metabolism; Alterations in enzyme activity caused by infection; Perturbations in hepatic drug m[more...]
An investigation of the function of carriers in polyester dyeing Kulube, H.M. , 1998-03 The purpose of this study was to quantify the amounts of individual carrier components left in the dyebath after a single dyeing in order to develop an insight into the mechanism of carrier action and, ultimately, to assess reusability and environm[more...]
Effect of schistosome infection on hepatic drug metabolising enzymes Naik, Yogeshkumar S. ; Hasler, Julia A. , 1998-06 Schistosomiasis is a parasitic disease that affects over 200 million persons worldwide.' The disease is caused by infection with any one of several species that are known to affect humans. Infected persons are likely to be consuming a wide spectru[more...]
Effect of schistosome infection on hepatic drug metabolising enzymes Naik, Yogeshkumar S. ; Hasler, Julia A. , 1998-06 Schistosomiasis is a parasitic disease that affects over 200 million persons worldwide.' The disease is caused by infection with any one of several species that are known to affect humans. Infected persons are likely to be consuming a wide spectru[more...]
Socio-economic aspects of animal power: a diagnostic study in Zimbabwe Tsimba, R. ; Chawatama, S. ; Mutimba, J. ; Ndlovu, P. ; Dzama, K. ; Topps, J.H. ; Hikwa, D. ; Mudhara, M. , 1999 A diagnostic participatory and questionnaire survey of 451 farmers was conducted in Tsholotsho, Chinyika and Mutoko Communal Areas in Zimbabwe to understand farmers’ crop production constraints in relation to draft power. Nearly half (49%) of all[more...]