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Alteration of paracetamol pharmacokinetics in BALB/C mice infected with Schistosoma mansoni

Show simple item record Mukanganyama, Stanley Naik, Yogeshkumar S. Hasler, Julia A. 2012-10-31T10:34:08Z 2012-10-31T10:34:08Z 1997
dc.description.abstract Objective: To determine whether the BALBIC mouse is a suitable model for the study of drug pharmacokinetics in S.rnansoni infection. Design: Male and female BALBIC mice were exposed to cercariae of Smansoni. At the acute (eight weeks post infection) and chronic (14 weeks post infection) stages of infection the animals were treated (i.p.) with a single injection of paracetamol. The pharmacokinetics of paracetamol were then determined for each group and compared to their respective controls. Subjects/Mode1: B ALBIC mice. Setting: Laboratory study. Main Outcome Measures: The altered pharamacokinetics observed in Smansoni infected mice are similar to those observed for humans. Results: Our data indicate that in both sexes of mice at both stages of infection with S.mansoni the Cmar was not dramatically reduced while the Tmax was delayed. The alterations are more pronounced at the chronic stage of infection. These results are similar to those obtained by other workers studying humans. Conclusion: The BALBIC mouse is likely to be a suitable model for the study of pharmacokinetics of selected drugs in schistosome infection. en_US
dc.description.sponsorship Research Board, University of Zimbabwe and the International Programme in Chemical Sciences, Uppsala Univerity, Sweden. en_US
dc.language.iso en en_US
dc.publisher Central African Journal of Medicine en_US
dc.subject Schistosoma mansoni en_US
dc.subject paracetamol en_US
dc.subject pharmacokinetics en_US
dc.title Alteration of paracetamol pharmacokinetics in BALB/C mice infected with Schistosoma mansoni en_US
dc.type Article en_US
dc.rights.license This article was downloaded from NUST Institutional repository, and is made available under the terms and conditions as set out in the Institutional Repository Policy. en_US

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