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  Chlorpyrifos- and dichorfos-induced oxidative and neurogenic damage elicits neuro-cognitive deficits and increases anxiety-like behaviors in wild-type rats Imam, Aminu ; Sulaiman, Nafeesah Abdulkareem ; Oyewole, Aboyeji Lukuman ; Chengetanai, Samson ; Williams, Victoria ; Ajibola, Musa Iyiola ; Folarin, Royhaan Olamide ; Muhammad, Asma’u Shehu ; Shittu, Asma’u Shehu ; Ajao, Salihu Moyosore , 2018-10-16 The mechanization of agricultural activities has led to indiscriminate deposition of toxic xenobiotics, including organophosphates in the biomes, and this has led to intoxication characterized with deleterious oxidative and neuronal changes. This st[more...]
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  Tunica vaginalis free graft urethroplasty: 10 years experience Ashmawy, Hassan ; Magama, Praise. T , 2018 Objective: To evaluate the long term patient outcomes over a 10 year period among 52 patients who had tunica vaginalis (TV) for substitution urethroplasty. Patients and methods: Between October 2005 and December 2015, a total of 52 patients had TV [more...]
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  Training initiatives within the AFHSC-Global Emerging Infections Surveillance and Response System: support for IHR (2005) Otto, Jean. L ; Baliga, Priya ; Sanchez, Jose. L ; Johns, Matthew. C ; Gray, Gregory.C ; Grieco, John , 2011 Training is a key component of building capacity for public health surveillance and response, but has often been difficult to quantify. During fiscal 2009, the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveill[more...]
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  Successful nonoperative management of high output enterocutaneous fistulae in high surgical risk HIV‐positive patients: Two case reports and literature review Muchuweti, David ; Muguti, Edwin. G ; Munganzi, Simbarashe. G , 2018-08-26 Management of enterocutaneous fistulae is challenging, often requiring a multidisciplinary approach. In high output fistulae, surgery is advocated after control of sepsis, adequate fluid and electrolyte repletion, and nutritional support. Surgery m[more...]
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  Risk of death among those awaiting treatment for HIV infection in Zimbabwe: adolescents are at particular risk. Shroufi, Amir ; Ndebele, Wedu ; Nyathi, Mary ; Gunguwo, Hilary ; Dixon, Mark ; Taziwa, Fabian , 2015-02-23 Introduction: Mortality among HIV-positive adults awaiting antiretroviral therapy (ART) has previously been found to be high. Here, we compare adolescent pre-ART mortality to that of adults in a public sector HIV care programme in Bulawayo, Zimbabwe[more...]
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  Prevalence of peritonitis and mortality in patients treated with continuous ambulatory peritoneal dialysis (CAPD) in Africa: a protocol for a systematic review and meta-analysis. Moloi, M.W ; Kajawo, S ; Noubiap, J.J ; Mbah, Ikechukwu. O ; Kengne, A.P , 2018-05-24 Introduction Continuous ambulatory peritoneal dialysis (CAPD) is the ideal modality for renal replacement therapy in most African settings given that it is relatively cheaper than haemodialysis (HD) and does not require in-centre care. CAPD is, h[more...]
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  Loss to follow-up among children and adolescents growing up with HIV infection: age really matters Kranzer, Katharina. ; Bradley, John. ; Musaazi, Joseph ; Ferrand, Rashida.A ; Ndhlovu, Mbongeni ; Apollo, Tsitsi , 2017-07-17 Introduction: Globally, increasing numbers of HIV-infected children are reaching adolescence due to antiretroviral therapy (ART). We investigated rates of loss-to-follow-up (LTFU) from HIV care services among children as they transition from childh[more...]
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  Investigating Avian Influenza Infection Hotspots in Old-World Shorebirds. Gaidet, Nicolas ; Ould El Mamy, A.B. ; Capelle, J. ; Caron, Alexandre ; Cumming, G.S. , 2012-09-28 Heterogeneity in the transmission rates of pathogens across hosts or environments may produce disease hotspots, which are defined as specific sites, times or species associations in which the infection rate is consistently elevated. Hotspots for av[more...]
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  Human immunodefciency virus associated pulmonary conditions leading to hospital admission and the pulmonary rehabilitation services received by patients at two central hospitals in Harare. Tadyanemhandu, C. ; Mupanda, C. ; Dambi, J. ; Chiwaridzo, M. ; Chikwasha, V. ; Chengetanai, S. , 2018-06-25 Objective: Use of highly active antiretroviral therapy has led to marked reductions in the incidence of HIV-associated opportunistic infections but has had comparatively less impact on the incidence of some pulmonary diseases. This study was done t[more...]
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  Effects of concurrent chloroquine and ethanol administration on the rat kidney morphology Abdulkadir, Abdurrahman ; Mbajiorgu, Ejikeme. F ; Nyirenda, Trust , 2018-01-18 The use of antimalarial chloroquine in malaria-endemic regions of Africa is rampant and it is not uncommon to find individuals taken the drug concurrent with alcohol. Effects of anti-malarial drug chloroquine (Chq) and ethanol (Et) combination on ki[more...]
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  Antimalarial Phytochemicals: Delineation of the Triterpene Asiatic Acid Malarial Anti-Disease and Pathophysiological Remedial Activities - Part I Mavondo, Greanious Alfred ; Kasvosve, Ishmael , 2018-05 Malaria is a composite condition of the Plasmodium parasite infection and accompanying pathologies. Parasite induced red blood cell perturbations and immunological response to infection drive various organ-specific syndromes accounting for a huge pe[more...]
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  Malaria Disease Perspective and an Opinion: Should Malaria Treatment Target the Parasite or the Malarial Pathophysiology Generated by the Parasite or Both? Mavondo, Greanious Alfred Alfrd , 2017-04-15 The malaria disease is caused by primarily four protozoan microorganisms of the Plasmodium genus transmitted by the female Anopheles mosquito namely: P. falciparum, P. vivax, P. Malariae, P. ovalae. A fourth one, P. knowlesi is known natural pathoge[more...]
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  The prevalence of pulmonary complications after thoracic and abdominal surgery and associated risk factors in patients admitted at a government hospital in Harare, Zimbabwe-a retrospective study Tadyanemhandu, C. ; Mukombachoto, Rufaro ; Nhunzvi, Clement ; Kaseke, Farayi ; Chikwasha, Vasco ; Chengetana, Samson ; Manie, Shamila , 2017 Background: The burden of HIV/AIDS in Sub-Saharan Africa has presented unusual and challenging acute surgical problems across all specialties. Thoraco-abdominal surgery cuts through muscle and thereby disrupts the normal anatomy and activity of the[more...]
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  Reducing fresh full term intrapartum stillbirths through leadership and accountability in a low-resource setting, Mpilo Central Hospital, Bulawayo, Zimbabwe Ngwenya, Solwayo , 2017-07-06 Background: Stillbirths are distressing to the parents and healthcare workers. Globally large numbers of babies are stillborn. A number of strategies have been implemented to try and reduce stillbirths worldwide. The objective of this study was to [more...]
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  Severe preeclampsia and eclampsia: incidence, complications, and perinatal outcomes at a low-resource setting, Mpilo Central Hospital, Bulawayo, Zimbabwe Ngwenya, Solwayo , 2017-05-17 Background: Severe preeclampsia is a disorder of pregnancy characterized by high blood pressure and significant proteinuria after 20 weeks gestation. Severe preeclampsia and eclampsia have considerable adverse impacts on maternal, fetal, and neonatal[more...]
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  Pre-treatment minority HIV-1 drug resistance mutations and long term virological outcomes: is prediction possible? Mzingwane, M.L. ; Tiemessen, C.T. ; Richter, K.L. ; Mayaphi, S.H. ; Hunt, G. ; Bowyer, S.M. , 2016-10-12 Background: Although the use of highly active antiretroviral therapy in HIV positive individuals has proved to be effective in suppressing the virus to below detection limits of commonly used assays, virological failure associated with drug resistanc[more...]
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  Effects of aqueous leaf extract of Asystasia gangetica on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats Mugabo, Pierre ; Raji, Ismaila A. , 2013-09-26 Background: Asystasia gangentica (A. gangetica) belongs to the family Acanthaceae. It is used to treat hypertension, rheumatism, asthma, diabetes mellitus, and as an anthelmintic in South Africa, India, Cameroun, Nigeria, and Kenya respectively. It h[more...]
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  The contributions of muscarinic receptors and changes in plasma aldosterone levels to the anti-hypertensive effect of Tulbaghia violacea Raji, Ismaila A. ; Mugabo, Pierre ; Obikeze, Kenechukwu , 2013 Background: Tulbaghia violacea Harv. (Alliaceae) is used to treat various ailments, including hypertension (HTN) in South Africa. This study aims to evaluate the contributions of muscarinic receptors and changes in plasma aldosterone levels to its a[more...]
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  Postpartum hemorrhage: incidence, risk factors, and outcomes in a low-resource setting Ngwenya, Solwayo , 2016-11-02 Background: Primary postpartum hemorrhage (PPH) is defined as blood loss from the genital tract of 500 mL or more following a normal vaginal delivery (NVD) or 1,000 mL or more following a cesarean section within 24 hours of birth. PPH contributes sig[more...]
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  Adaptation and implementation of local maternity dashboards in a Zimbabwean hospital to drive clinical improvement Crofts, J. ; Moyo, J. ; Ndebele, W. ; Mhlanga, Samson ; Draycott, T. ; Sibanda, T. , 2013-11-27 Problem:The Commission on Information and Accountability for Women’s and Children’s Health of the World Health Organization (WHO) reported that national health outcome data were often of questionable quality and “not timely enough for practical use b[more...]

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